souped-up /ˈsuːpt ʌp/ adjective5 •Improved.As with the previous Omicron subvariants, it seems likely that the US will follow those regions once again, with or without the new souped-up vaccines. — 2022 •(slang) Of an engine, a motor vehicle, etc.: modified for higher performance.$600.00 BUYS T. M. Scout with "Souped up" OX5 motor. Snappiest commercial single seater built. H. W. Mackie, Air Service, Houston, Texas. — 1925 •(US, slang) Intoxicated by alcohol or drugs. •(US, slang) Excited. •Of a racehorse: injected with a substance to make it run faster or to change its temperament. formsmore souped-up · most souped-up