Houston UK /ˈh(j)uːst(ə)n/US /ˈhjustən/ noun1 •A large city, the county seat of Harris County, Texas, United States, named after Sam Houston.The family’s ordeal began last month, when they were rushing from Rio Grande City, where they lived, to Houston, where their daughter’s specialist doctors are based, for an emergency medical checkup. — 2025 formsHoustons