prefoldin noun1 •Any of a family of proteins used in protein-folding complexes. A prefoldin molecule works as a transfer protein in conjunction with a molecule of chaperonin to form a chaperone complex and correctly fold other nascent proteins.The same attributes are found in a very similar eukaryotic cytosolic chaperone, prefoldin, which assists in binding cytoskeletal unfolded proteins. — 2015 formsprefoldins