molecule UK /ˈmɒl.ɪ.kjuːl/US /ˈmɑ.lɪ.kjul/ noun2 •The smallest particle of a specific element or compound that retains the chemical properties of that element or compound; two or more atoms held together by chemical bonds.Hydrogen chloride is a diatomic molecule, consisting of a hydrogen atom and a chlorine atom. •A tiny amount. formsmoleculae · molecules