chaperone UK /ˈʃæ.pəˌɹəʊn/US /ˈʃæ.pəˌɹoʊn/noun 3verb 2forms 3 noun3 •An older person who accompanies other younger people to ensure the propriety of their behaviour, often an older woman accompanying a young woman. •A protein that assists the non-covalent folding/unfolding and the assembly/disassembly of other macromolecular structures, but does not occur in these structures when the latter are performing their normal biological functions. •(UK) An employee sent by a British company to the European Union to work with a client there, to circumvent restrictions imposed after Brexit. verb2 •To act as a chaperone.They played you off very cunning, Eliza. If it had been only one of them, you could have nailed him. But you see, there was two; and one of them chaperoned the other, as you might say. — 1912 •(UK) To work as a chaperone. formschaperoned · chaperoning · chaperones