pathognomonic UK /ˌpaθəɡnə(ʊ)ˈmɒnɪk/US /ˌpæθəɡnoʊˈmɑːnɪk/ adjective1 •specifically characteristic or indicative of a particular disease or condition.A tetrad of rash, arthralgia, abdominal pain and kidney disease in a child is pathognomonic for Henoch-Schönlein purpura.