irritate

verb4

1. •
   To provoke impatience, anger, or displeasure in.

   • If thou irritatest my lord, there will come to war against thee all the Getulians, Numidians, and Garamantes, Afric contains. — 1814
2. •
   To cause or induce displeasure or irritation.
3. •
   To induce pain in (all or part of a body or organism).
4. •
   (no longer used) To render null and void.

   • Are human laws presently superfluous, so often as they do not irritate or abrogate Divine laws ? — 1634