irritation /ˌɪɹ.ɪˈteɪ.ʃən/ noun5 •The act of irritating or annoying.What irritation causes you to be so moody? •The state of being irritated.CNN spoke recently with several Conyers residents who said they still have blurry vision, shortness of breath, throat irritation or chronic headaches since the chemical plant fire. — 2024 •A state of inflammation or of painful reaction to cell or tissue damage. •A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.Hip pain is a common complaint in children and may indicate a very mild irritation in the hip joint or may be the symptom of a very severe abnormality — 1975 •A thing or person that annoys. formsirritations