arthritis UK /ɑːˈθɹ(a)ɪtɪs/US /ɑɹˈθɹ(a)ɪtɪs/ noun1 •Inflammation of a joint or joints causing pain and/or disability, swelling and stiffness, and due to various causes such as infection, trauma, degenerative changes or metabolic disorders: any of several disease entities.The suppurating osteo-myelitis and arthritis did not assume a form sufficiently putrid to cause purulent infection; the patient also escaped hecticity — 1878 formsarthritides · arthritises