agonist /ˈæɡəˌnɪst/ noun3 •A molecule that can combine with a receptor on a cell to produce a physiological reaction.Acetylcholine is an agonist at the cholinergic receptor. •The muscle that contracts while the other relaxes.When bending the elbow, the biceps is the agonist. •Someone involved in a contest or battle (as in an agon), protagonist. formsagonists