zonifugal adjective1 •Proceeding out of a zone or region from inside that zone or region, as with an examination beginning in a body part affected by a drug or disease and moving from there to a normal body part.In the latter case, the zonifugal test, we start from the anesthetic region and the patient is asked to state when the tactile sense becomes apparent. — 1908 formsmore zonifugal · most zonifugal