zidovudine UK /zɪˈdɒv.jʊ.diːn/US /zɪˈdoʊ.vjəˌdin/ noun1 •A nucleoside analog reverse-transcriptase inhibitor C₁₀H₁₃N₅O₄, a type of antiretroviral drug that inhibits replication of some retroviruses (such as HIV) and was first approved for the treatment of AIDS. formszidovudines