tweaked adjective3 •(slang) Hallucinating, especially under the influence of crystal meth or similar narcotics. •(slang, figurative) On edge, nervous, tense.I don't know why, but Koops has been acting odd lately. What could be bothering him? Probably nothing. He's always tweaked about something. — 2004 •(slang, figurative) Broken, messy, out of order. formsmore tweaked · most tweaked