trephine /tɹɪˈfaɪn/verb 2noun 1forms 3 verb2 •To use a trephine during surgery. •To perforate with a trephine. noun1 •A surgical instrument with a cylindrical blade used to remove a circular section of tissue, such as bone or cornea; a trepan.They removed a core of bone as well as took a bone marrow aspirate from my right hip using a trephine to exclude me having blood cancer, causing a blood- and serum-stained shirt, a whopping hematoma and a great deal of mental anguish and physical pain in the process! formstrephined · trephining · trephines