seropositive adjective 2noun 1forms 1 adjective2 •Of blood serum, testing positive for a given pathogen, especially HIV (HIV positive). •Of a person or animal, having seropositive blood serum.They offer individual and group counseling to seropositive individuals, street outreach education, and an educational workshop series for people at risk. — 1990 noun1 •A person with such blood serum. formsseropositives