sads noun[plural only]1 •(informal) Sadness or melancholy.Lauris also tells the story of her putting some of her M&Ms into a bottle and calling them "Happiness Pills," which she sweetly offered when Martha had an episode of the Sads." — 1996
SADS noun3 •Initialism of sudden arrhythmic death syndrome. •Initialism of sudden adult death syndrome. •Initialism of swine acute diarrhea syndrome.