regretfully adverb2 •In a regretful manner, with regret.The steak and chips partaken of for lunch seemed now to belong to another decade. He regretfully recognized the fact that he would not make a success of a hunger strike. — 1922 •(nonstandard) Unfortunately, in a manner inspiring or deserving regret; used only as a sentence adverb (to introduce and modify an entire sentence). formsmore regretfully · most regretfully