refractory /ɹɪˈfɹæk.tə.ɹi/adjective 4noun 2forms 3 adjective4 •Obstinate and unruly; strongly opposed to something.[…] in most instances attempts to coerce the refractory and disobedient have been the signals of bloody wars, […] — 1787 •Resistant to treatment; not responding adequately to therapy.Many of the vague and refractory cases of neck and shoulder pain and of migraine may be due to cervical disc disease. — 1949 •Not affected by great heat.Pure lime is extremely refractory, but readily fusible if any silex is brought in contact with it; […] — 1855 •Incapable of registering a reaction or stimulus.The production of a generator potential leaves a refractory state in the receptor membrane […] — 1959 noun2 •A material or piece of material, such as a brick, that has a very high melting point. •A plant or factory that produces such material. formsrefractories · more refractory · most refractory