prognosis UK /pɹɒɡˈnəʊsɪs/US /pɹɑɡˈnoʊsɪs/ noun2 •A forecast of the future course or outcome of a situation based on what is presently known; a prediction.I may say here that it is one of the evidences of original character, that it is apt to baffle all prognosis from a mere observer's standpoint. — 1879 •A forecast of the future course or outcome of a disease or disorder based on current medical knowledge.Hovvbeit it is to be noted (vvhich vve hinted in the prognosis) that the svvelling doth often appear critically and profitably, and thereby the sick are recovered of their diseases; […] — 1655 formsprognoses