port of entry noun2 •A harbor, airport, or border crossing where goods or immigrants enter a country.The Motor Carrier Act that opened the U.S. side of the U.S.-Mexican border shows that on average 46.4. local trucking and courier service establishments left each port of entry. — 2014 •The location or mechanism by which a foreign entity gains entry into the body or self.Furthermore when the bacteria become pathogenic, the nasopharynx is the port-of-entry of the infection. — 2010 formsports of entry