plague spot noun3 •A spot on the skin that is characteristic of the plague or of a similar disease.But no plague-spot appeared, and when Steb woke up in the afternoon and demanded something to eat, it was pretty evicent that he was merely suffering from a feverish cold. — 1881 •A location where plague is active.He notes that South Elmham deanery 'appears to have been a plague spot', but regrettably he supplies no reason for its unenviable condition. — 2005 •(figurative) A location that is a plague or scourge; a place of corruption and degeneracy. formsplague spots