penicillin /ˌpɛn.ɪˈsɪl.ɪn/ noun2 •Any of a group of narrow-spectrum antibiotics obtained from Penicillium molds or synthesized, that have a beta-lactam structure and are active against gram-positive bacteria and used in the treatment of various infections and diseases. •A blue mold of the genus Penicillium that produces penicillin. formspenicillins