operating UK /ˈɒpəɹeɪtɪŋ/US /ˈɑpəɹeɪtɪŋ/adjective 2noun 1 adjective2 •In operation; that operates.Don't touch the operating machinery. •Involved in an operation.The team arbitrarily chose that one operating frame of reference which we all use today. noun1 •Synonym of operation (in the uncountable sense).Sure, academic medicine is fascinating — but operating is the reason I became a surgeon.Operating on conscious patients involves some additional considerations.