operate UK /ˈɒpəɹeɪt/US /ˈɑpəɹeɪt/ verb8 •to work the controls of equipment or a vehicle so that it does what it shouldTermokarstovoye is 250 km east of Tarkosale where Novatek operates a processing facility for its own onshore production. — 2009 •To perform a work or labour; to exert power or strength, physical or mechanical; to act.Could someone explain how this meeting operates?In this town, the garbage removal staff operate between six o'clock at midnight. •To perform some manual act upon a human body in a methodical manner, and usually with instruments, with a view to restore soundness or health, as in amputation, lithotomy, etc.The surgeon had to operate on her heart.I'm being operated tomorrow. •To produce an effect. •To produce an appropriate physical effect; to issue in the result designed by nature; especially (medicine) to take appropriate effect on the human system.The drug operates by facilitating the negative neurotransmitter gamma-aminobutyric acid (GABA), resulting in the blocking of neural long-term potentiation. — 2010 •To act or produce an effect on the mind; to exert moral power or influence.A plain, convincing reason operates on the mind both of a learned and ignorant hearer as long as they live. — 1720 •To bring about as an effect; to cause.Strictures upon style, which are for the most part good, but time has operated a change in many respects even since he wrote. — 1830 •To deal in stocks or any commodity with a view to speculative profits. formsoperated · operating · operates