nuclein UK /ˈnjuː.klɪ.ɪn/US /ˈn(j)u.kli.ɪn/ noun1 •A phosphorus-rich protein found in the nucleus of a cell, later specifically nucleohistone or nucleoprotamine; also, any similar compound present in the cell nucleus.While delving microscopically through the pus in surgical bandages, Miescher found a substance he didn't recognize and called it nuclein (because it resided in the nuclei of cells). — 2003 formsnucleins