nettlesome /ˈnɛtəlsəm/ adjective2 •Causing irritation, annoyance, or discomfort; bothersome, irksome.My old car is very nettlesome. •Thorny; difficult to deal with, especially due to being complex or tricky.The task of proving Fermat’s “last” theorem remains nettlesome.Be careful what you say to him; he's a nettlesome fellow. formsmore nettlesome · most nettlesome