Neo-Babylonian adjective 1noun 1forms 1 adjective1 •(historical) Of or relating to the Neo-Babylonian Empire or Second Babylonian Empire, the last polity ruled by monarchs native to Mesopotamia. It was founded in 626 BC and conquered by the Achaemenid Persian Empire in 539 BC. noun1 •(historical) An inhabitant of the Neo-Babylonian Empire. formsNeo-Babylonians