methylprednisolone UK /ˌmiː.θʌɪl.pɹɛdˈnɪs.ə.ləʊn/US /ˌmɛθ.əl.pɹɛdˈnɪs.əˌloʊn/ noun1 •A synthetic glucocorticoid, C₂₂H₃₀O₅, used chiefly in the treatment of inflammatory and autoimmune disorders.The patient was treated with methylprednisolone, cyclophosphamide, and azathioprine, as well as burn center protocol care with daily tankings. — 1993 formsmethylprednisolones