cyclophosphamide UK /ˌsʌɪ.kləʊˈfɒs.fə.mʌɪd/US /ˌsaɪ.kloʊˈfɑs.fəˌmaɪd/ noun1 •An immunosuppressive, antineoplastic drug used in the treatment of Hodgkin's disease and certain other forms of cancer.The patient was treated with methylprednisolone, cyclophosphamide, and azathioprine, as well as burn center protocol care with daily tankings. — 1993 formscyclophosphamides