mainline /ˈmeɪnˌlaɪn/adjective 7noun 7verb 4forms 3 adjective7 •Normal, principal or standard. •Of or pertaining to the principal route or line of a railway. •Pertaining to a direct route between two major ports. •Of a sequence of opening moves: being part of a main line ("a standard sequence of opening moves considered to be best play").Short's pragmatic approach to the match was to avoid mainline theory and the teenager's computer preparation. — 2010 •Of or pertaining to a surface-level heavy rail system as distinct from an underground, elevated or light rail one. •Of or pertaining to national or long-distance rail network operators as opposed to urban and suburban operators.Merseyrail and mainline services affected by downpour with more heavy rain forecast — 2019 •(US) Not fundamentalist, charismatic or evangelical.At a time when mainline denominations are engaged in massive closures of small rural churches, independent charismatics are strategically helping to rechurch rural Canada. — 2010 noun7 •The principal route or line of a railway. •In longline fishing the central line to which the branch lines with baits are attached. •The pipeline carrying wastewater to the public drains or a septic tank. •The main repository for a software project, from which different versions (forks) may be split off. •(slang) A principal vein into which a drug can be injected.I'm searching for my mainline / I said I couldn't hit it sideways — 1968 •An airline's main operating unit, as opposed to codeshares or regional subsidiaries. •The general population of a prison. verb4 •(slang) To inject (a drug) directly into a vein.The patient skinpopped for 1½ years and then started to mainline heroin. — 1968 •(informal) To consume voraciously.Last month, she lamented that her busy campaign schedule had kept her from mainlining Amazon’s new “Rings of Power” series. — 2022 •To integrate (code, etc.) into the main repository for a software project, rather than separate forks. •To include (a prisoner) in the general population of a prison. formsmainlined · mainlining · mainlines