lobotomy UK /ləˈbɒtəmi/US /ləˈbɑtəmi/ noun3 •(historical) A surgical operation involving cutting into a lobe of a body organ, specifically (neurosurgery), a procedure, now largely disused, involving severing connections between the prefrontal cortex and the thalamic region of the frontal lobe of the brain to treat certain mental illnesses. •(historical) An operation involving the severing of the sympathetic nerve trunk. •(figurative) An act of removing or separating, and often disregarding or forgetting, something.Put another way, how can we avoid an ethical lobotomy in establishing an organizational perspective? — 2002 formslobotomies