cortex UK /ˈkɔːtɛks/US /ˈkɔɹtɛks/ noun3 •The outer layer of an internal organ or body structure, such as the kidney or the brain. •The tissue of a stem or root that lies inward from the epidermis, but exterior to the vascular tissue. •The outer surface of a piece of flint. formscortexes · cortices