irritant /ˈɪɹɪtənt/adjective 2noun 2forms 1 adjective2 •Causing irritation or inflammation. •(Scotland) Rendering null and void; conditionally invalidating.The states elected Harry, Duke of Anjou, for their king, with this clause irritant; that, if he did violate any part of his oath, the people should owe him no allegiance. — 1603 noun2 •Any medication designed to cause irritation •A source of irritation. formsirritants