hyoscyamine UK /ˌhʌɪ.ə(ʊ)ˈsʌɪ.ə.miːn/US /ˌhaɪ.əˈsaɪ.əˌmin/ noun1 •A poisonous alkaloid present in henbane that is the stereoisomer of atropine, with similar properties to hyoscine, and used medicinally to treat abdominal pain and similar conditions.If only Creake was going to poison his wife with hyoscyamine and bury her, instead of blowing her up with a dynamite cartridge and claiming that it came in among the coal. — 1914 formshyoscyamines