homotopic UK /həʊ̯.məʊ̯ˈtɒp.ɪk/US /hoʊ̯.moʊ̯ˈtɑp.ɪk/ adjective3 •Such that there is a homotopy (a continuous deformation) taking one to the other.f and g are homotopic. •Having to do with or being a part of the correspondent region in the other brain hemisphere.In somatosensory cortex, homotopic connections would be limited to portions of representations devoted to the body midline. — 2013 •(rare) Homorganic.