homolog UK /ˈhɒməlɒɡ/US /ˈhɑːməlɑːɡ/ noun5 •Something homologous; a homologous organ or part, chemical compound, chromosome, gene, or cultural element. •A phoneme, morpheme, or word shared by two languages or dialects, via cognation or naturalization. •One of a group of similar DNA sequences that share a common ancestry, or the peptides or proteins that they encode; the counterpart gene or protein in another taxon evolved from a common ancestor (molecularly it may be either identical or similar).TP53 is the human homolog of murine Trp53. •A member of a homologous series. •A belief, practice, concept, or artifact that has a counterpart in another culture. formshomologs