holdase noun1 •A particular kind of molecular chaperone that assists the non-covalent folding of proteins in an ATP-dependent manner. Holdases bind to protein folding intermediates to prevent their aggregation but without directly refolding them.As a part of that network, holdase chaperones are able to communicate with other chaperones in the network, to achieve refolding of misfolded clients. — 2015 formsholdases
