goofball /ˈɡufˌbɔl/noun 2adjective 1forms 1 noun2 •(informal) A foolish or silly person or animal.If that goofball would put half the effort into her studies as she does into her juggling, she might do very well. •(informal) A pill or tablet containing a pharmaceutical which has hypnotic or intoxicating effects, especially a barbiturate.Strong Cobb & Co. of Cleveland announced a new barbiturate which in overlarge doses will turn the stomachs of "goofball" addicts and would-be suicides. — 1953 adjective1 •(informal) Silly.He announced, with his usual goofball humor, that he'd like to marry me! formsgoofballs