barbiturate /ˌbɑː(ɹ)ˈbɪt͡ʃəɹɪt/ noun2 •Any salt or ester of barbituric acid. •Any of derivatives of barbituric acid that act as depressants of the central nervous system and are used as sedatives or hypnotics.Chlorpromazine should be taken with caution in combination with barbiturates, sleeping pills, narcotics, or any other medication which may produce a depressive effect. Avoid alcohol. — 1979 formsbarbiturates