exhaustion

noun5

1. •
   The point of complete depletion, of the state of being used up.

   • We worked the mine to exhaustion, there's nothing left to extract.
2. •
   Supreme tiredness; having exhausted energy.

   • I ran in the marathon to exhaustion, then I collapsed and had to be carried away.
3. •
   An exhaustive procedure
4. •
   (old-fashioned) The removal (by percolation etc) of an active medicinal constituent from plant material.
5. •
   (old-fashioned) The removal of all air from a vessel (the creation of a vacuum).