depletion /dɪˈpliːʃən/ noun4 •The act of depleting, or the state of being depleted; exhaustion.The Great Northern 4-4-0s have all vanished, and there has been some depletion in the ranks of North British "Glens" and "Scotts." — 1954 •The consumption of a resource faster than it can be replenished. •gradual expense or use of natural resources over time. •(no longer used) The act of relieving congestion or plethora, by purging, blood-letting, or reduction of the system by abstinence. formsdepletions