drospirenone /dɹoʊˈspɪɹ.əˌnoʊn/ noun1 •A synthetic progestogen C₂₄H₃₀O₃ that is an analog of spironolactone and is used in birth control pills in combination with ethinylestradiol (trademarks Yasmin and Yaz).But Yaz contains drospirenone, a progestin that can cause excess potassium production in some patients, its side effects include an increased risk of serious heart and other health problems. — 2009