distemperate

adjective3

1. •
   (no longer used) Immoderate, excessive.

   • Thou hast thy brain distemperate, and out of rule.
2. •
   (no longer used) Not temperate, of no good influence for one's confort or soundness; (figuratively) unwholesome, stormy.
3. •
   (no longer used) Not properly tempered; disordered through excess or deficiency of some constituent; (by extensions, of bodily or mental condition) disordered, out of order; diseased, out of health; ill-conditioned.