unwholesome UK /ˌənˈhəʊlsəm/US /ˌənˈhoʊlsəm/ adjective3 •Not wholesome; unfavorable to health; unhealthful.Caliban: As wicked dewe, as ere my mother brush'd / With Rauens feather from vnwholesome Fen / Drop on you both : A Southwest blow on yee, / And blister you all ore. — 1610 •Not sound; tainted; defective.There was something indefinably unwholesome about him. Something lean and snakelike. — 2022 •Indicating unsound health; characteristic of or suggesting an unsound condition, physical or mental; repulsive; offensive. formsmore unwholesome · most unwholesome