bilious UK /ˈbɪl.i.əs/US /ˈbɪl.jəs/ adjective4 •Of or pertaining to something containing or consisting of bile. •Suffering from real or supposed liver disorder, especially excessive secretions of bile.Perry tells me that Mr. Cole never touches malt liquor. You would not think it to look at him, but he is bilious—Mr. Cole is very bilious. — 1815 •Peevishly ill-humored, irritable or bad tempered; irascible.The boarders, sharp-tongued bilious widows, pursued the only man in the establishment, a mild, bald creature who worked in La Samaritaine […] — 1934 •Resembling bile, especially in color.Does money fail?—come to my mint—coin paper, Till gold be at a discount, and ashamed To show his bilious face, go purge himself, In emulation of her vestal whiteness. — 1820 formsmore bilious · most bilious