benzodiazepine /ˌbɛnzoʊdaɪˈæzɪpiːn/ noun1 •Any of a class of psychoactive drugs, structured upon diazepine, used in the treatment of anxiety, insomnia and other related disorders.That week we were in the desert I couldn't sleep—perhaps a couple of hours each night at the most even with a steady intake of benzodiazepine. — 2023 formsbenzodiazepines