psychoactive /ˌsaɪkoʊˈæktɪv/adjective 1noun 1forms 3 adjective1 •Affecting the mind or mental processes.LSD and DMT are psychoactive drugs. noun1 •Any drug that affects the mind or mental processes.LSD and DMT are psychoactives. formspsychoactives · more psychoactive · most psychoactive