YOLO UK /ˈjəʊləʊ/US /ˈjoʊloʊ/verb 1phrase 1forms 3 verb1 •To make the most of the present moment. phrase1 •(slang) Acronym of you only live once, i.e. expressing the view that one should make the most of the present moment.Making this cake mix eleven years past the expiration date, because YOLO! formsYOLOed · YOLOing · YOLOs