virulent UK /ˈvɪɹ(j)ʊl(ə)nt/US /ˈvɪɹ(j)ələnt/ adjective4 •Of animals, plants, or substances: extremely venomous or poisonous. •(figurative) Extremely hostile or malicious; intensely acrimonious.The politicians were virulent in their hatred of the president. •Of a disease or disease-causing agent: malignant, able to cause damage to the host. •Of a pathogen: replicating within its host cell, then immediately causing it to undergo lysis. formsmore virulent · most virulent