vicissitude /vɪˈsɪs.ɪˌt(j)uːd/ noun2 •[in the plural] A change, especially in one's life or fortunes.And God made.. the Stars, and set them in the firmament of Heaven to illuminate the Earth, and rule the day in their vicissitude... — 1667 •Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange; variability. formsvicissitudes